I have missed two shots around 125 yards or so however, but both times I believe operator error was the cause. I missed the 6 point a day before I was lucky enough to get a second shot at him because I did not have a steady rest and rushed my shot. I missed last years doe before I had dropped her in her tracks at 50 yards due to forgetting about tree branches I was using for cover being right in front of the barrel. In neither case do I believe the bullet dropped too much at the 100+ yard distance. Ideally I like to keep my muzzleloader shots within a 100 yards but I make sure to sight in 2 inches high at 75 yards to allow for some drop with my heavier bullet in my allocated effective/maximum (and comfortable) range of 150 yards with this gun.
I'll leave you with the only con I have for this gun: The ramrod. It has a twist out end used to lengthen it by a few inches that I find annoying to use as it doesn't want to hold very well when extended. My original ramrod also had issues with rattling and not stay put in its holder area under the barrel, though the new one I got for it at Christmas does stay put, so far.
All-in-all, CVA makes great guns and my Optima is one of them. I'd suggest it to anyone looking for a new muzzleloader or wanting to get into the sport.
-C.B.